Erythema annulare centrifugum and pregnancy

A 28‐year‐old woman came to our attention in the 33rd week of her first pregnancy with a 2‐week history of asymptomatic skin eruptions on the arms and legs. She was otherwise well and no other symptoms were present. She used only vitamin and iron supplements during pregnancy. The eruption began as erythematous papules before spreading peripherally while clearing centrally. This produced polycyclic plaques with indurated margins and trailing scales on the inner aspect of the advancing edge. The diameter of the lesions varied from a few to several centimeters ( Fig. 1). 1Superficial erythema annulare centrifugum: a central clearing and “trailing scale” behind an advancing, annular, erythematous border Complete blood count, renal, liver, and thyroid function tests, Lyme antibody titer, antinuclear antibody test, urinary analysis, and stool examination gave normal results. A potassium hydroxide preparation and culture were negative for the presence of tinea or candidiasis. A chest X‐ray was performed after delivery and a negative result was obtained. Histology showed spongiosis associated with parakeratosis in the epidermis and a dense perivascular lymphocytic infiltrate in the upper dermis ( Fig. 2). Direct immunofluorescence was negative. 2Histopathology showing a perivascular lymphocytic infiltrate in the upper dermis (hematoxylin and eosin, × 10) At the 38th week, the patient gave birth to a healthy baby, weighing 3000 g. All skin lesions gradually disappeared within 1 month after delivery, without any treatment, except for petrolatum. No recurrence was seen after 8 months.