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Clinical, histopathologic, and therapeutic aspects of subepidermal autoimmune bullous diseases with IgG on the floor of salt‐split skin
Author(s) -
Barnadas Maria A.,
González Ma José,
Planagumà Mercè,
Romaní Jordi,
Curell Román,
De Moragas José Ma,
Alomar Agustí
Publication year - 2001
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1046/j.1365-4362.2001.01188.x
Subject(s) - medicine , bullous pemphigoid , dapsone , prednisone , direct fluorescent antibody , pemphigoid , dermatology , dermatitis herpetiformis , pathology , immunofluorescence , autoimmune disease , antibody , disease , immunology , gastroenterology
Background About 12% of patients with subepidermal autoimmune bullous disease and immunoglobulin G (IgG) at the dermal–epidermal junction present diseases other than bullous pemphigoid. Materials and methods We report the clinical, histopathologic, and therapeutic aspects of eight cases of subepidermal bullous disorder with IgG on the floor of salt‐split skin. Results A predominant neutrophilic infiltrate was detected in six of the eight patients. In one patient, the inflammatory infiltrate was neutrophilic and eosinophilic in the same proportion. A good response to dapsone alone or combined with prednisone was observed in six patients. Conclusions The salt‐split skin direct immunofluorescence test is useful for its diagnostic and therapeutic implications.