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Ecthyma gangrenosum
Author(s) -
Güçlüer Hülya,
Ergun Tülin,
Demirçay Zeynep
Publication year - 1999
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1046/j.1365-4362.1999.00691.x
Subject(s) - medicine , chills , leukopenia , surgery , lesion , white blood cell , anemia , amikacin , gastroenterology , antibiotics , chemotherapy , microbiology and biotechnology , biology
Case 1. An 18‐year‐old white man with AML‐M3 received allogeneic bone marrow transplantation (BMT) in August 1997. On the seventh day of BMT, he developed chills, fever (39.1 °C), anorexia, and perirectal pain. On physical examination, a hemorrhagic bulla and “punched out” ulceration were observed on the perirectal region. Subsequently, the ulcer was surrounded by a red, swollen, tender, cellulitic plaque ( Fig. 1). 1The ulceration on the perianal region of the first patient Laboratory analyses showed leukopenia (200/mm 3 ) with anemia (hemoglobin (Hb), 10.5 g/dL) and thrombocytopenia (17,000/mm 3 ). Tzanck test of the lesion was negative. The direct examination of the ulcer material revealed leukocytes and Gram‐negative bacilli, but no pathogen grew on culture. Blood and catheter cultures revealed Pseudomonas aeruginosa . Intravenous imipenem, 2 g/day, and amikacin, 1 g/day, were started. The lesion resolved within 3 weeks following antibiotic treatment and surgical debridement.