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Epidermodysplasia verruciformis with neurological manifestations
Author(s) -
Rubaie Salah Al,
Breuer Judith,
Inshasi Jihad,
Saady Samira Al,
Fathi Iman
Publication year - 1998
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1046/j.1365-4362.1998.00399.x
Subject(s) - epidermodysplasia verruciformis , medicine , etretinate , dermatology , genodermatosis , hyperkeratosis , acitretin , dyskeratosis , angiokeratoma , mucocutaneous zone , pathology , psoriasis , disease , virus , virology , biochemistry , chemistry , gene
Background Epidermodysplasia verruciformis (EV) is a rare, inherited disorder in which there is widespread and persistent infection by multiple subtypes of human papilloma virus, tinea versicolor‐like lesions and plaques, and frequently malignant manifestations. Materials and methods We report two cases of EV—a sister and brother aged 14 and 18 years respectively. Both had classical skin lesions together with neurological manifestations and deafness. In addition the man had plantar hyperkeratosis. They were treated with etretinate. Conclusions PCR and DNA hybridization of skin lesions from the man contained HPV‐20 and HPV‐57. He was treated with long‐term oral acitretin; the warty lesions became partly or wholly flattened and the plantar hyperkeratosis showed a remarkable improvement. The woman died 10 years later as a result of metastasizing breast cancer.