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Autoimmune progesterone dermatitis: effective prophylactic treatment with danazol
Author(s) -
Shahar Eduardo,
Bergman Reuven,
Pollack Shimon
Publication year - 1997
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1046/j.1365-4362.1997.00105.x
Subject(s) - danazol , medicine , regimen , treatment modality , dermatology , immunology , endometriosis
Background Autoimmune progesterone dermatitis is a rare condition appearing during the perimenstrual period or following progesterone treatment. Various treatment modalities have been suggested, but most have proved to be ineffective. Methods We used the anabolic androgen danazol as a preventive treatment for recurrent episodes of autoimmune progesterone dermatitis in two young women. The treatment regimen consisted of 200 mg danazol twice daily, starting 1–2 days before the expected date of each menses and continuing for 3 days thereafter. Results This treatment regimen proved to be highly effective in preventing the eruptions in these two patients. Conclusions Patients with autoimmune progesterone dermatitis may benefit from prophylactic treatment with danazol.