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Evaluation of the clinical and serum IgE responses to oral challenge with cornstarch, corn, soy and a soy hydrolysate diet in dogs with known food allergy
Author(s) -
Jackson H. A.,
Hammerberg B.,
Jackson M. W.,
Coblentz L.
Publication year - 2002
Publication title -
veterinary dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.744
H-Index - 60
eISSN - 1365-3164
pISSN - 0959-4493
DOI - 10.1046/j.1365-3164.2002.00298_14.x
Subject(s) - hydrolysate , soy protein , medicine , food allergy , allergy , immunoglobulin e , oral food challenge , food science , allergen , soy milk , immunology , biology , hydrolysis , antibody , biochemistry
Hydrolysate diets have been advocated in the management of the food‐allergic dog, but little information is available on their performance in dogs with known allergies. Fourteen dogs with known allergies to soy and corn were maintained on a limited antigen diet exclusively for 80 days (Hills d/d Rice and Duck, Hills Pet Nutrition, Topeka, KS). This diet was continued during oral challenge with 200 mg kg −1 of cornstarch, corn and soy respectively on two occasions each at 24‐h intervals. There was a minimum period of 15 days between each challenge. A diet containing hydrolysed soy protein and cornstarch (CNM HA, Ralston Purina Co., St. Louis, MO) was then introduced. Before and after each oral challenge the dogs were examined and a clinical score was determined; serum was also collected for measurement of allergen‐specific and total IgE concentrations. Statistical analysis employed the use of a longitudinal mixed model and was performed using SAS software (Cary, NC). Significant increases in clinical scores were seen after oral challenge with cornstarch, corn and soy ( P = 0.04, 0.002, 0.01 respectively) but not with HA ( P = 0.5), although three dogs did develop clinical signs after this latter challenge. Allergen challenge did not affect total serum IgE concentrations. Although increases in soy‐ and corn‐specific serum IgE were measured in individual dogs post‐challenge they were not statistically significant, and could not be used to predict clinical hypersensitivity. This study was funded by a grant from Ralston Purina Co., St. Louis, MO.