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Comparison of T‐lymphocyte proliferation in canine epitheliotropic lymphosarcoma and benign lymphocytic dermatoses
Author(s) -
Murphy Marcia K.,
Olivry Thierry
Publication year - 2000
Publication title -
veterinary dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.744
H-Index - 60
eISSN - 1365-3164
pISSN - 0959-4493
DOI - 10.1046/j.1365-3164.2000.00190.x
Subject(s) - mycosis fungoides , medicine , cd3 , pathology , dermis , proliferating cell nuclear antigen , t cell , erythema , atypical lymphocyte , dermatology , antigen , immunology , lymphoma , immunohistochemistry , immune system , cd8
The lesions of patch/plaque cutaneous T‐cell lymphosarcoma (CTCL) are similar to many benign inflammatory dermatoses, both histopathologically and clinically. In humans, attempts to develop a simple, reliable immunophenotypic technique to differentiate between the malignant and benign dermatoses have been unsuccessful. The purpose of our study was to determine, using a proliferating cell nuclear antigen (PCNA)/CD3 double immunolabelling technique of paraffin‐embedded sections, if the rate of T‐cell proliferation in canine CTCL was greater than that of other diseases with non‐neoplastic lymphocyte epitheliotropism. We selected cases of patch/plaque (PP) and tumour stage CTCL, erythema multiforme (EM) and cutaneous lupus erythematosus (CLE). We did not find a significant difference in the rate of T‐cell proliferation in the epithelia nor the superficial dermis between PP‐CTCL and EM. Whereas epithelial T‐cell proliferation is significantly higher in PP‐CTCL than CLE, it is not diagnostically useful because of overlap in the labelling indices.