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Malignant transformation of a giant congenital pigmented nevus (hamartoma) in a dog
Author(s) -
Valentiné,
McManus,
Knox
Publication year - 1999
Publication title -
veterinary dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.744
H-Index - 60
eISSN - 1365-3164
pISSN - 0959-4493
DOI - 10.1046/j.1365-3164.1999.00130.x
Subject(s) - melanoma , malignant transformation , hamartoma , pathology , medicine , dermis , anatomy , nevus , dermatology , cancer research
A male Golden Retriever was born with a large area of abnormal skin and hair on the distal pelvic limb. A tumour arose from the proximal margin of this area at 5 years of age. Histopathological examination of the abnormal area of skin revealed an area in which follicles were surrounded by nodular accumulations of densely packed round to spindle‐shaped cells with fine granular intracytoplasmic melanin. Similar cells were present within the subcutaneous fat, and clusters of densely pigmented melanocytes were scattered within the basal epidermis, follicular epithelium, and dermis. A diagnosis of giant congenital pigmented nevus (hamartoma) was made. The tumour from the proximal end of this area was composed of densely packed, moderately pleomorphic, poorly differentiated and pigmented, spindle‐shaped to epithelioid melanocytes, and was diagnosed as malignant melanoma. Metastasis of the malignant melanoma to the stifle and inguinal regions occurred within 6 months. To date, the authors are unaware of prior reports of a canine giant congenital pigmented nevus (hamartoma) with transformation to a malignant melanoma.