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Cryoglobulinaemia and cryofibrinogenaemia: a comparison of canine and human cases
Author(s) -
Makoto Nagata,
Nanko,
Y. Hashimoto,
Takumi Ogawa,
Sakashita
Publication year - 1998
Publication title -
veterinary dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.744
H-Index - 60
eISSN - 1365-3164
pISSN - 0959-4493
DOI - 10.1046/j.1365-3164.1998.00108.x
Subject(s) - eosinophilic , pathology , breed , dermis , medicine , fibronectin , epidermis (zoology) , lymph , biology , anatomy , extracellular matrix , zoology , biochemistry
A 1‐year‐old, male mixed‐breed dog developed dark brown, demarcated necrotic lesions on the pinnae. The owner noticed, in late November, that the dog, which had been kepy outdoors, was feeling pain in the area of the pinnae. Histopathological examination revealed dilated vessels containing an amorphous eosinophilic substance and erythrocytes. In addition, the epidermis and dermis were eosinophilic and amorphous due to degeneration. Cooling of the serum and plasma produced precipitation, and these proteins dissolved after rewarming. SDS–PAGE analysis showed that the serum and plasma cryogels corresponded to IgG and IgM and to purified fibronectins and fibrinogens, respectively. This dog has been kept indoors since the onset of the disease, and no underlying disorders have been found during a follow‐up period of 1 year. These findings suggest that the present case closely resembles essential mixed cryoglobulinaemia and cryofibrinogenaemia in humans. This report also includes observations of a human patient and discusses similarities between the canine and human manifestations of the disease.