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What is the effect of combining artesunate and praziquantel in the treatment of Schistosoma mansoni infections?
Author(s) -
Clercq D.,
Vercruysse J.,
Verlé P.,
Kongs A.,
Diop M.
Publication year - 2000
Publication title -
tropical medicine and international health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.056
H-Index - 114
eISSN - 1365-3156
pISSN - 1360-2276
DOI - 10.1046/j.1365-3156.2000.00628.x
Subject(s) - praziquantel , artesunate , schistosoma mansoni , medicine , helminthiasis , significant difference , schistosomiasis , anthelmintic , gastroenterology , immunology , helminths , veterinary medicine , malaria , plasmodium falciparum
Summary A group of 110 individuals with Schistosoma mansoni infection was investigated. Patients were allocated to one of three treatment groups and given artesunate or praziquantel alone or both in combination. Combined artesunate–praziquantel significantly increased the number of individuals cured at 5 weeks post‐treatment, but at 12 weeks was only better than artesunate alone and at 24 weeks there was no statistically significant difference between the three groups. Egg count reduction rate was similar to the rate obtained with praziquantel used alone.