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Yellow fever vaccination during pregnancy and spontaneous abortion: a case‐control study
Author(s) -
De A. Nishioka Sérgio,
NunesAra£jo F. R. F.,
Pires Waldely P.,
Silva Flávia A.,
Costa Hégena L.
Publication year - 1998
Publication title -
tropical medicine and international health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.056
H-Index - 114
eISSN - 1365-3156
pISSN - 1360-2276
DOI - 10.1046/j.1365-3156.1998.00164.x
Subject(s) - medicine , abortion , pregnancy , odds ratio , dengue fever , vaccination , obstetrics , confounding , logistic regression , case control study , gynecology , pediatrics , immunology , genetics , biology
objective To assess a possible association between Yellow fever (YF) vaccine (inadvertently) administered during early pregnancy and spontaneous abortion. method A hospital‐based case‐control study conducted in a Brazilian town after a YF vaccine campaign that followed an epidemic of dengue. The study included 39 women who attended a university hospital with spontaneous abortion (cases) and 74 pregnant women attending the antenatal clinic of that hospital (controls). results The crude odds ratio (relative risk estimate) of this association was 2.49, which dropped to 2.29 (95% CI 0.65–8.03) when adjusted for several confounders by multiple logistic regression. Dengue and exposure to organophosphate insecticide fogging during pregnancy were not associated with spontaneous abortion. conclusion This study, although small and with low power, provides some evidence that women vaccinated with YF vaccine during early pregnancy have an increased risk of having spontaneous abortion. Based on these findings a sensible recommendation should be to avoid YF vaccination of pregnant women unless their risk of acquiring YF outweighs the risk of vaccine‐related abortion.