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Assessment of the incidence of substandard drugs in developing countries
Author(s) -
Shakoor O.,
Taylor R. B.,
Behrens R. H.
Publication year - 1997
Publication title -
tropical medicine and international health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.056
H-Index - 114
eISSN - 1365-3156
pISSN - 1360-2276
DOI - 10.1046/j.1365-3156.1997.d01-403.x
Subject(s) - medicine , incidence (geometry) , drug , developing country , quality (philosophy) , environmental health , toxicology , pharmacology , mathematics , biology , philosophy , geometry , epistemology , ecology
In a number of developing countries there is reportedly a high incidence of the availability of substandard drugs. The majonty of these reports do not contain quantitative data to support these claims, nor do they describe the methodology employed for the quality assessment. Many assume counterfeiting as the reason for the poor quality and in some cases this is not justified. We collected 96 samples of chloroquine and selected antibacterials from Nigeria and Thailand in a controlled and methodical manner and analysed them using appropriately validated methods based on high‐performance liquid chromatography capable of detecting drug‐related impurities and quantifying active drug(s). The results indicate that 36.5% of the samples were substandard with respect to pharmacopoeial limits. Decomposition was the cause of poor quality in a number of the samples but overall, poor manufacturing appeared to be prevalent. The analyses generated little evidence to indicate fraudulent manufacturing. Treatment failure and drug‐resistance are possible consequences of the use of substandard drugs.