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The first example of anti‐Diego b found in a Polish woman with the Di(a+b–) phenotype and haemolytic disease of the newborn not requiring treatment
Author(s) -
Lenkiewicz B.,
Żupańska B.
Publication year - 2003
Publication title -
transfusion medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.471
H-Index - 59
eISSN - 1365-3148
pISSN - 0958-7578
DOI - 10.1046/j.1365-3148.2003.00437.x
Subject(s) - haemolytic disease , phenotype , medicine , disease , clinical phenotype , pediatrics , immunology , pathology , biology , pregnancy , genetics , fetus , gene
Summary. All pregnant women with anti‐Diego b (anti‐Di b ) described so far were non‐Caucasians. We present the case of a Polish Di(a+b–) woman with anti‐Di b , which did not bind complement, was immunoglobulin G3 (IgG3) alone and had very low functional activity. She delivered a Di(a+b+) infant with a positive direct antiglobulin test and the antibody in his serum but very mild haemolytic disease. Both parents of the pregnant woman were Di(a+b+), so were all her three children. The whole family have been living in a small village in southeastern Poland for a long time. The rare Diego phenotypes, found now and previously in Poland, suggest gene admixture introduced as a result of Poland being invaded by Mongolian‐background Tatars during the past centuries.