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Isoimmune neonatal neutropenia due to anti‐Fc gamma RIIIb antibody in a mother with an Fc gamma RIIIb deficiency
Author(s) -
Maślanka K.,
Guz K.,
Uhrynowska M.,
Żupańska B.
Publication year - 2001
Publication title -
transfusion medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.471
H-Index - 59
eISSN - 1365-3148
pISSN - 0958-7578
DOI - 10.1046/j.1365-3148.2001.00294.x
Subject(s) - neutropenia , antibody , immunology , granulocyte , monoclonal antibody , medicine , pregnancy , antigen , virology , biology , genetics , chemotherapy
A rare case of neutropenia in a newborn due to anti‐Fc gamma RIIIb antibody is described. The newborn, born from the 5th pregnancy, had severe infection and no neutrophils. Full clinical and neutrophil count recovery was observed when the child was 5 weeks old. In maternal serum, panreactive granulocyte alloantibodies were detected. The mother's and her two sisters' granulocytes appeared to be Fc gamma RIIIb deficient as found using pheno‐ and genotyping methods. All of them were healthy. The anti‐Fc gamma RIIIb specificity of antibodies was identified by the monoclonal antibody immunobilization of neutrophil antigen assay. Such antibodies were not found in both sisters with the Fc gamma RIIIb deficiency, although they were pregnant, one of them on the seventh occasion.