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Platelet washing to prevent recurrent febrile reactions to leucocyte‐reduced transfusions
Author(s) -
Vo T. D.,
Cowles J.,
Heal J. M.,
Blumberg N.
Publication year - 2001
Publication title -
transfusion medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.471
H-Index - 59
eISSN - 1365-3148
pISSN - 0958-7578
DOI - 10.1046/j.1365-3148.2001.00280.x
Subject(s) - platelet , medicine , saline , platelet transfusion , cohort , anesthesia , immunology
Symptoms of fever and/or rigours after transfusion continue to occur commonly in patients receiving platelets leucocyte‐reduced after storage. A cohort of 24 consecutive patients who had experienced severe or repeated febrile nonhaemolytic reactions to post‐storage leucocyte‐reduced platelet transfusions were treated with saline‐washed, post‐storage leucocyte‐reduced platelets. The frequency of reactions declined from 20% of transfusions ( n = 191) to 0·6% ( n = 331) after instituting saline‐washed, post‐storage leucocyte‐reduced platelet transfusions. These results support the hypothesis that substances present in the supernatant of stored platelet concentrates mediate febrile nonhaemolytic transfusion reactions, and provide one strategy for preventing their occurrence.