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Isolation of human mannan binding lectin, serum amyloid P component and related factors from Cohn Fraction III
Author(s) -
Kilpatrick D. C.
Publication year - 1997
Publication title -
transfusion medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.471
H-Index - 59
eISSN - 1365-3148
pISSN - 0958-7578
DOI - 10.1046/j.1365-3148.1997.d01-40.x
Subject(s) - mannan , serum amyloid p component , fractionation , fraction (chemistry) , biochemistry , innate immune system , chemistry , immune system , lectin , plasma protein binding , polysaccharide , biology , immunology , chromatography , c reactive protein , inflammation , receptor
Cohn Fraction III, a waste product of plasma fractionation, is a source of several proteins involved in host defence as part of the innate immune system. Here a procedure is described for purifying mannan binding lectin and serum amyloid P component to virtual homogeneity from Cohn Fraction I + III, and their separation from other mannan‐binding factors and from C‐reactive protein. It is suggested that products derived from Cohn Fraction III could have therapeutic potential, either for specific substitution therapy or as a combined package of innate immune factors.