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Post‐transfusion purpura (PTP) associated with anti‐HPA‐1a, anti‐HPA‐2b and anti‐HPA‐3a antibodies
Author(s) -
Lucas G. F.,
Pittman S. J.,
Davies S.,
Solanki T.,
Brüggemann K.
Publication year - 1997
Publication title -
transfusion medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.471
H-Index - 59
eISSN - 1365-3148
pISSN - 0958-7578
DOI - 10.1046/j.1365-3148.1997.d01-39.x
Subject(s) - antibody , platelet , immunology , medicine , neonatal alloimmune thrombocytopenia , purpura (gastropod) , platelet membrane glycoprotein , antigen , glycoprotein , biology , microbiology and biotechnology , pregnancy , ecology , fetus , genetics
The serum from an 85‐year‐old man with a clinical diagnosis of post‐transfusion purpura (PTP) was investigated for the presence of platelet‐specific antibodies. Clinically, the case was typical of PTP but, unusually, the serum was found to contain multiple platelet‐specific alloantibodies. Anti‐HPA‐1a, anti‐HPA‐2b and anti‐HPA‐3a antibodies were detected together with multispecific anti‐HLA (class I) antibodies. Additional (but weaker) antibody reactivity was also observed with platelet glycoproteins (Gp) IIb/IIIa, GpIb and GpIa/IIa which lacked the antigens recognized by the alloantibodies, suggesting the presence of auto‐ or cross‐reacting antibodies. The patient's genotype was HPA‐1b/1b, HPA‐2a/2a, HPA‐3b/3b, HPA‐5a/5b and was consistent with the platelet alloantibodies detected. The patient made a complete recovery following treatment with intravenous gamma‐globulin.