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DBT: a partial D phenotype associated with the low‐incidence antigen Rh32
Author(s) -
Wallace M.,
LomasFrancis C.,
Beckers E.,
Bruce M.,
Campbell G.,
Chatfield S.,
Nagao N.,
Okubo Y.,
Opalka A.,
Overbeeke M.,
Scott M.,
Voak D.
Publication year - 1997
Publication title -
transfusion medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.471
H-Index - 59
eISSN - 1365-3148
pISSN - 0958-7578
DOI - 10.1046/j.1365-3148.1997.d01-32.x
Subject(s) - incidence (geometry) , phenotype , medicine , antigen , immunology , biology , genetics , gene , mathematics , geometry
Eight probands are described with a D phenotype in which a partial D antigen is associated with Rh32 antigen; three of these probands were investigated because of the anti‐D in their serum. The partial D lacks epD1–epD5 and epD9 and some epD6/7 and only expresses epD8 and other parts of epD6/7. The strength of the partial D antigen varies between unrelated DBT individuals. The Rh32 antigen of the DBT cells is weaker than that of D(C)(e) cells. Tests on DBT, DFR and R 0 Har cells with anti‐epD6/7 split these monoclonal anti‐D into eight patterns of reaction. A new pattern of reactions was observed, presaging a new epitope, but this was not numbered.