Premium
Frequency and specificity of platelet‐specific alloantibodies in HLA‐immunized haematologic–oncologic patients
Author(s) -
Schnaidt M.,
Northoff H.,
Wernet D.
Publication year - 1996
Publication title -
transfusion medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.471
H-Index - 59
eISSN - 1365-3148
pISSN - 0958-7578
DOI - 10.1046/j.1365-3148.1996.d01-58.x
Subject(s) - medicine , platelet , isoantibodies , antigen , immunology , antibody , human leukocyte antigen , monoclonal antibody , neonatal alloimmune thrombocytopenia , immunization , pregnancy , fetus , biology , genetics
The frequency and specificity of platelet‐alloantibodies to human platelet antigens (HPA) ‐1, ‐3 and ‐5 was investigated in 59 multitransfused, HLA‐immunized patients. Using the MAIPA test (monoclonal antibody specific immobilization of platelet antigens) platelet alloantibodies could be demonstrated in 10 (17%) patients. In one patient the antibody was present prior to any transfusions and probably induced by multiple previous pregnancies. This antibody was directed to HPA‐5b. The remaining nine antibodies were found in patients ( n = 36) with HLA‐antibodies reacting with over 95% of unselected lymphocytes. In these patients the target antigens were HPA‐1b in six, HPA‐3a in one and both antigens in two patients. Our findings demonstrate platelet alloimmunization induced by transfusions to be restricted to patients with high HLA‐immunization. 25% of these patients (9/36) show platelet‐specific antibodies, primarily HPA‐1b.