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Regulation of T Helper Cell Differentiation In Vivo by GP43 from Paracoccidioides brasiliensis Provided by Different Antigen‐Presenting Cells
Author(s) -
Ferreira K. S.,
Lopes J. D.,
Almeida S. R.
Publication year - 2003
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1046/j.1365-3083.2003.01291.x
Subject(s) - paracoccidioides brasiliensis , paracoccidioidomycosis , biology , immunology , cd40 , antigen presenting cell , interleukin 12 , antigen , immune system , interleukin 4 , t cell , in vivo , interleukin 21 , interferon gamma , cytotoxic t cell , microbiology and biotechnology , in vitro , biochemistry
Paracoccidioidomycosis, endemic in Latin America, is a progressive systemic mycosis caused by Paracoccidioides brasiliensis . The infection can evolve into different clinical forms that are associated with various degrees of suppressed cell‐mediated immunity. Assuming that the effector immune response is a consequence of the preferential activation of either Th1 or Th2 subsets, in the present work we evaluated whether the nature of antigen‐presenting cells (APCs) can influence the Th1/Th2 balance in vivo . It was observed that the injection of mature dendritic cells (DCs), macrophages and B cells primed the mice and induced a proliferation of T cells in vitro . It was seen that DCs from resistant mice stimulated predominantly interleukin‐2 (IL‐2) and interferon‐γ (IFN‐γ), whereas macrophages activated IL‐10, IL‐4 and IFN‐γ‐secreting T cells and B cells IL‐4 and IL‐10 only. Results presented here clearly demonstrate that DC drives the development of cells secreting Th1‐derived cytokines, whereas B cells induce the differentiation of a Th2 phenotype in vivo .