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γδ T Cells and Interleukin‐6 Levels Could Provide Information Regarding the Progression of Human Renal Allograft
Author(s) -
Borel I. Malan,
Racca A.,
Garcia M. I.,
Bailat A.,
Quiroga F.,
Soutullo A.,
Gaite L.
Publication year - 2003
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1046/j.1365-3083.2003.01275.x
Subject(s) - flow cytometry , cd8 , kidney , medicine , interleukin 2 , immunology , receptor , endocrinology , immune system
We have determined the percentage of αβ and γδ T cells by flow cytometry as well as serum interleukin‐6 (IL‐6) and soluble interleukin‐6 receptor (sIL‐6R) levels by enzyme‐linked immunosorbent assay in kidney allograft recipients with acute, chronic or stable graft evolution. The percentage of CD4 and CD8 T cells in transplanted patients was lower than in the control group ( P < 0.001) with the exception of CD8 γδ T cells from patients with stable evolution ( P > 0.05). The serum levels of IL‐6 and sIL‐6R in acute and chronic rejection were higher than in the controls ( P < 0.05). No differences in IL‐6 levels were observed between the stable evolution and the control groups ( P > 0.05). The levels of sIL‐6R were higher in stable evolution patients than in the controls ( P < 0.05) and no differences were observed between the chronic and stable evolution patients ( P > 0.05). IL‐6 decreased in patients with a favourable evolution, increased in those with an increased renal dysfunction and was maintained when the renal dysfunction was not modified. These results suggest that γδ T cells could participate in renal allograft maintenance and that IL‐6 but not sIL‐6R serum levels may provide a prognostic marker for measuring the evolution of kidney allograft.