Premium
Sporothrix schenckii Lipid Inhibits Macrophage Phagocytosis: Involvement of Nitric Oxide and Tumour Necrosis Factor‐α
Author(s) -
Carlos I. Z.,
Sgarbi D. B. G.,
Santos G. C.,
Placeres M. C. P.
Publication year - 2003
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1046/j.1365-3083.2003.01175.x
Subject(s) - sporotrichosis , sporothrix schenckii , nitric oxide , macrophage , phagocytosis , phagocytic cell , microbiology and biotechnology , pathogenesis , necrosis , tumor necrosis factor alpha , immune system , sporothrix , immunology , biology , chemistry , pathology , medicine , biochemistry , in vitro , endocrinology
The role of cell‐wall compounds in the immune response to sporotrichosis is unknown. The effect of cell‐wall compounds and exoantigen obtained from Sporothrix schenckii in macrophage/fungus interaction was analysed with respect to nitric oxide (NO) and tumour necrosis factor‐α (TNF‐α). The lipid compound of the cell wall plays an important role in the pathogenesis of this mycosis and was found to inhibit the phagocytic process and to induce high liberation of NO and TNF‐α in macrophage cultures in the present study. This is a very interesting result because it is the first report about one compound of the fungus S. schenckii that presents this activity.