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Production of Antibodies against Glycolipids from the Mycobacterium tuberculosis Cell Wall in Aerosol Murine Models of Tuberculosis
Author(s) -
Cardona P. J.,
Julián E.,
Vallès X.,
Gordillo S.,
Muñoz M.,
Luquin M.,
Ausina V.
Publication year - 2002
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1046/j.1365-3083.2002.01088.x
Subject(s) - antibody , antigen , mycobacterium tuberculosis , glycolipid , tuberculosis , microbiology and biotechnology , biology , immunology , mycobacterium , humoral immunity , antibiotics , virology , medicine , pathology
Evolution of antibodies against glycolipids from the Mycobacterium tuberculosis cell wall has been studied for the first time in experimental murine models of tuberculosis induced by aerosol, in which infection, reinfection, reactivation, prophylaxis and treatment with antibiotics have been assayed. Results show a significant humoral response against these antigens, where diacyltrehaloses (DAT) and sulpholipid I (SL‐I) elicited higher antibody levels than protein antigens like antigen 85 protein complex (Ag85), culture filtrate proteins (CFP) and purified protein derivative (PPD). Only immunoglobulin M (IgM) antibodies have been detected against DAT and SL‐I. Their evolution has a positive correlation with bacillary concentration in tissues.