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To be or Not to be Ridded? – That is the Question Addressed by the Associative Antigen Recognition Model *†
Author(s) -
Cohn M.,
Langman R. E.
Publication year - 2002
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1046/j.1365-3083.2002.01059.x
Subject(s) - repertoire , antigen , effector , sort , biology , immune system , immunology , germline , associative property , computational biology , class (philosophy) , genetics , evolutionary biology , communication , gene , computer science , psychology , artificial intelligence , mathematics , physics , information retrieval , acoustics , pure mathematics
The reasons that germline‐encoded recognitive sites cannot sort the immune system's large and random somatically generated repertoire into anti‐Not‐to‐be‐ridded (‘self ’) and anti‐To‐be‐ridded (‘nonself ’) specificities are analysed. The immune system cannot use ‘nonself ’‐markers of To‐be‐ridded antigens (‘Danger’, toll receptors, pathogenicity, localization, etc.) to sort the repertoire; it may, however, use them to determine the magnitude and class of the effector response.