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Primary Immunodeficiency Diseases: Natural Mutant Models for the Study of the Immune System
Author(s) -
Fischer A.
Publication year - 2002
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1046/j.1365-3083.2002.01056.x
Subject(s) - primary immunodeficiency , immunodeficiency , immune system , immunology , severe combined immunodeficiency , biology , mutant , common variable immunodeficiency , gene , virology , computational biology , genetics , antibody
Primary immunodeficiency diseases represent many natural mutant models for the analysis of many aspects of immunology. Examples dealing with T‐ and B‐cell receptors are herein discussed. They also represent privileged models in medicine, because well characterized monogenic inherited diseases can in some instances be viewed as good targets for gene therapy as shown here for severe combined immunodeficiency (SCID).