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Effects of Indomethacin on the l ‐selectin Expression in Humans
Author(s) -
Dirnberger E.,
Albinni S.,
Röggla M.,
Jilma B.
Publication year - 2001
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1046/j.1365-3083.2001.00995.x
Subject(s) - in vivo , in vitro , dexamethasone , placebo , pharmacology , l selectin , medicine , chemistry , biology , biochemistry , pathology , receptor , alternative medicine , microbiology and biotechnology
Based on an in vitro study and an uncontrolled in vivo trial we examined the effects of indomethacin on the expression of l ‐selectin by leukocytes in healthy volunteers. Eight subjects received infusions of 0.7 mg/kg indomethacin and placebo t.i.d. (three times daily) in a randomized, controlled trial. Indomethacin decreased the mean fluorescence intensity of the l ‐selectin expression on isolated neutrophils incubated with toxic indomethacin concentrations. However, indomethacin did not lower the l ‐selectin expression in whole blood or in‐vivo . Thus, therapeutic doses of the cyclo‐oxygenase inhibitor indomethacin do not lower the l ‐selectin expression on leukocytes. Hence, the inhibition of cyclo‐oxygenase cannot explain the previously observed dexamethasone‐induced decrease in l ‐selectin.