Premium
Th1‐specific Bystander Costimulation Imparts Resistance against Mycobacterium tuberculosis Infection
Author(s) -
Das G.,
Vohra H.,
Saha B.,
Mishra G. C.
Publication year - 2000
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1046/j.1365-3083.2000.00808.x
Subject(s) - mycobacterium tuberculosis , tuberculosis , immunology , bystander effect , antigen presentation , microbiology and biotechnology , cytokine , antigen , secretion , biology , immune system , t cell , virology , medicine , pathology , biochemistry
The protection against Mycobacterium tuberculosis infection is mediated by T helper type‐1 (Th1) cells. Infection of BALB/ c mice with M. tuberculosis downregulates expression of a Th1‐specific costimulatory molecule, M150, on the surface of infected macrophages. The proliferation of Th cells and Th1‐cytokine production by these cells are higher in case of M. tuberculosis antigen presentation by uninfected macrophages than by infected macrophages. The difference in inducing interleukin(IL)‐2 and interferon (IFN)‐γ secretion is abolished by providing bystander costimulation through M150 on liposomes.