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Immature B Cells in Bone Marrow Express Fas/FasL
Author(s) -
Mats Nilsson,
Pär K. Ingvarsson,
Borrebaeck
Publication year - 2000
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1046/j.1365-3083.2000.00701.x
Subject(s) - bone marrow , fas ligand , fas receptor , cd19 , biology , immunology , antigen , cd40 , negative selection , apoptosis , microbiology and biotechnology , cancer research , cytotoxic t cell , in vitro , gene , programmed cell death , genome , biochemistry
Negative selection is a process by which autoreactive lymphocytes are eliminated from the developing antigen receptor repertoire. The mechanisms regulating negative selection of immature B lymphocytes in the bone marrow are poorly elucidated. Human bone marrow cells were examined in order to investigate the presence of the members of the Fas (APO‐1/CD95) system. Here we demonstrate the expression of Fas in immature B lymphocytes (CD10/CD19 + /CD40 + /sIg + ), and the presence of Fas natural ligand (FasL) in CD19 + bone marrow cells. The observed expression of apoptosis‐related molecules might indicate how negative selection of autoreactive B cells can occur in human bone marrow.