Premium
Genes, Receptors, Signals and Responses to Lipopolysaccharide Endotoxin
Author(s) -
Pierre Wong,
S W Chugn,
Barnet M. Sultzer
Publication year - 2000
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1046/j.1365-3083.2000.00689.x
Subject(s) - lipopolysaccharide , cd14 , signal transduction , receptor , gene , biology , septic shock , immunology , microbiology and biotechnology , sepsis , genetics
C3H/HeJ inbred mice have been very useful for identifying genetic elements responsible for endotoxin‐mediated responses. Depending on the type of assays employed, Tlr‐2, Tlr‐4 and Lps/Ran have been shown to be important in lipopolysaccharide (LPS)‐mediated responses. The concept of a single LPS gene being responsible for the genetic defect found in C3H/HeJ mice should therefore be re‐examined more closely. Given the most recent discoveries, it is probable that more than one signal transduction pathway is involved. One is a CD14‐dependent pathway, the other a CD14‐independent pathway. Identification of the genetic elements involved in these pathways will be beneficial in designing therapeutic strategies for treating patients with endotoxic or septic shock.