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Chemokine Receptors and their Crucial Role in Human Immunodeficiency Virus Infection: Major Breakthroughs in HIV Research
Author(s) -
Thomas Birk Kristiansen,
EugenOlsen
Publication year - 1998
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1046/j.1365-3083.1998.00438.x
Subject(s) - human immunodeficiency virus (hiv) , chemokine receptor , virology , biology , virus , immunology , immune system , chemokine receptor ccr5 , chemokine , phenotype , viral entry , gene , viral replication , genetics
Within the last three years, major progress in the understanding of acquired immune deficiency syndrome pathogenesis has been achieved. The discovery that human immunodeficiency virus (HIV), in addition to the CD4 receptor, requires the presence of a coreceptor in order to infect cells has led to a series of breakthroughs in HIV research and knowledge. These include an increased understanding of viral entry, a connection of viral phenotype to specific coreceptor use, and an unequivocal linkage of a single human gene to host susceptibility. All in all these achievements provide a number of promising new strategies for combating HIV.