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Differential Expression of T‐Cell Adhesion Molecules and LFA‐1‐Dependent Intercellular Adhesion in HgCl 2 ‐Induced Autoimmunity and Immune Suppression
Author(s) -
Anja Roos,
Nike Claessen,
Esther J.M. Schilder-Tol,
Jan J. Weening,
Jan Aten
Publication year - 1998
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1046/j.1365-3083.1998.00414.x
Subject(s) - cd8 , lymphoblast , autoimmunity , immune system , chemistry , t cell , icam 1 , intracellular , lymphocyte , t lymphocyte , microbiology and biotechnology , cell adhesion , intercellular adhesion molecule 1 , phorbol , immunology , biology , cell , cell culture , biochemistry , signal transduction , genetics , protein kinase c
Exposure of Brown Norway (BN) rats to HgCl 2 induces Th2‐mediated systemic autoimmunity. In contrast, in Lewis rats, HgCl 2 induces immune suppression, mediated by CD8 + T cells. HgCl 2 was previously found to enhance expression of LFA‐1, ICAM‐1 and CD134 (OX40) on T cells in BN rats. In the present study, T cells from Lewis rats were studied at day 4 after injection of HgCl 2 . CD8 + T lymphoblasts were significantly increased, which were predominantly CD45RC hi , and which showed enhanced LFA‐1 expression. Furthermore, CD4 + CD45RC hi T cells showed increased numbers of ICAM‐1 + cells, whereas expression of CD134 and CD26 was relatively decreased in CD4 + T lymphoblasts. Ex vivo experiments demonstrated that HgCl 2 ‐ exposure of BN rats, but not of Lewis rats, significantly enhances PMA [phorbol 12‐myristate 13‐acetate]‐induced lymphocyte aggregation, mediated by LFA‐1 and ICAM‐1. In conclusion, HgCl 2 ‐injected Lewis rats show early signs of T‐lymphocyte activation, predominantly on CD8 + cells. Strain‐dependent effects of HgCl 2 on cell adhesion molecules and expression of CD134 may play an important role in development of either autoimmunity or immune suppression.