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Prostaglandin‐Independent Stimulation of Interleukin‐6 Production by Fibrinogen Degradation Product D in Perfused Murine Liver
Author(s) -
Miklós Csala,
István Léránt,
Gábor Bánhegyi,
Tamás Kardon,
Ferenc Puskás,
I. Muchá,
Raymund Machovich,
András Falus,
József Mandl
Publication year - 1998
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1046/j.1365-3083.1998.00395.x
Subject(s) - stimulation , chemistry , prostaglandin , endocrinology , medicine , fibrinogen , prostaglandin e , interleukin , cytokine , biochemistry
Bacterial endotoxin (LPS) and fibrinogen degradation product D (FDP‐D) are both potent stimulators of interleukin‐6 (IL‐6) production in liver, however, there are differences in their metabolic effects. The aim of the present study was to compare the role of prostaglandins in the enhancement of IL‐6 production by LPS or FDP‐D in perfused mouse livers. Indomethacin inhibited the effect of LPS significantly but was ineffective in the case of FDP‐D. Accordingly, production of prostaglandins D 2 and E 2 was not elevated following the addition of FDP‐D, while their formation was increased several fold by LPS. At the same time interleukin‐1 (IL‐1) production in perfused liver rose markedly upon the addition of FDP‐D. It is suggested that prostaglandins are not involved in the effects of FDP‐D on the liver. The stimulatory effect of FDP‐P on IL‐6 production might be the consequence of elevated IL‐1 levels.