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Release of the Soluble Co‐Receptor (Protein Fv) of Secretory Immunoglobulins after Colonization of Axenic Rats by the Human Gut Microflora
Author(s) -
C.P. Andrieux,
René Pirès,
Moreau Mc,
Bouvet Jp
Publication year - 1998
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1046/j.1365-3083.1998.00381.x
Subject(s) - colonization , axenic , antibody , microbiology and biotechnology , secretory iga , receptor , biology , chemistry , immunology , bacteria , biochemistry , genetics
The presence of protein Fv (pFv), a soluble co‐receptor of human gut antibodies, was investigated in heteroxenic rats as a function of the presence of the human digestive microflora. This endogenous molecule was not detected in the stools of axenic rats but was found in those of heteroxenic animals. The release was delayed for 1 week after colonization and found to be independent from the kinetics of bacteria‐induced short‐chain fatty acids issued from the catabolism of carbohydrates and of proteins. The similar bacterial composition of pFv‐positive and of pFv‐negative stools, and the lack of induction by different dominant bacterial genera, suggest that non‐dominant species must be involved. These results indicate that human colonic flora is a major inducer of pFv and thus participates in increasing the efficiency of the intestinal immunity by this additional mechanism known to maintain and augment the polymeric status of secretory immunoglobulin (Ig)A.