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Antigenic Phenotype of Early Intra‐Embryonic Lymphoid Progenitors in the Chicken
Author(s) -
M. Lampisuo,
Kaisa Katevuo,
O. Lassila
Publication year - 1998
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1046/j.1365-3083.1998.00361.x
Subject(s) - embryonic stem cell , progenitor cell , biology , haematopoiesis , microbiology and biotechnology , stem cell , antigen , immunology , genetics , gene
The stem cells for the definitive haematopoiesis are derived from intra‐embryonic sources originally described in an avian model and later also in mammals. However, the molecular make‐up of the early embryonic haematopoietic progenitors is not yet clearly defined. We have recently characterized the phenotype of prethymic intra‐embryonic progenitors capable of thymic colonization. Here we studied the ontogeny of cell‐surface antigens HEMCAM, α2β1 integrin, thrombomucin, chL12 and c‐kit and their co‐expression on prethymic T‐cell progenitors. The early intra‐embryonic expression of avian B‐cell antigen chB6 was also demonstrated on cells derived from the intra‐embryonic areas. We suggest that in the chicken, embryonic B‐cell progenitors segregate earlier than T‐cell progenitors in the differentiation of multipotent haematopoietic stem cells to committed progenitors.