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Increased Levels of Soluble Tumour Necrosis Factor Receptor‐I (P55) and Decreased IgG1 Reactivities in HIV‐1 Patients with Cytomegalovirus Disease
Author(s) -
Palle Jakobsen,
Karen Kaae Dodt,
Christian Meyer,
Terese L. Katzenstein,
Jan Gerstoft,
Peter Skinhøj
Publication year - 1998
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1046/j.1365-3083.1998.00338.x
Subject(s) - cytomegalovirus , betaherpesvirinae , immunology , antibody , immunopathology , tumor necrosis factor alpha , viral disease , human cytomegalovirus , medicine , disease , subclass , receptor , virus , herpesviridae , virology
The purpose of the study was to investigate potential associations between tumour necrosis factor (TNF), soluble TNF receptors (sTNF‐Rs), immunoglobulin (Ig)G subclasses and development of cytomegalovirus (CMV) disease amongst human immunodeficiency virus (HIV)‐1 patients. We enrolled HIV‐1 patients with CD4 counts less than 100/μl in a prospective study and followed them over 1 year for development of CMV disease. Concentrations of TNF, sTNF‐RI, sTNF‐RII and IgG subclass reactivities were measured by ELISA; levels of CMV pp65 antigenaemia were determined as numbers of pp65 expressing cells/100 000 cells and were measured by staining of leucocytes; and HIV‐1 RNA loads were measured by polymerase chain reaction (PCR). Eighteen patients studied with CMV disease had higher levels of sTNF‐RI than 18 similar patients without CMV disease. Concentrations of sTNF‐RI correlated with levels of CMV antigenaemia in blood samples collected before the development of CMV disease. Patients with CMV disease had lower levels of IgG 1 reactivities to CMV than patients without CMV disease. We conclude that increased levels of sTNF‐RI and decreased IgG 1 reactivities are associated with an increased risk of development of CMV disease among HIV‐1 patients.