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The Simulation of Density‐Dependent Effects in the Recirculation of T Lymphocytes
Author(s) -
Dov J. Stekel
Publication year - 1998
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1046/j.1365-3083.1998.00329.x
Subject(s) - thoracic duct , lymphocyte , irradiation , lymphatic system , t lymphocyte , chemistry , biology , pathology , biophysics , immunology , physics , medicine , immune system , nuclear physics
T‐lymphocyte recirculation appears to be slower in nude or irradiated rats as compared with normal rats. A mathematical model of T‐lymphocyte recirculation that incorporates interactions between T cells and dendritic cells in the lymphoid tissue is presented. It is shown that these interactions are able to explain the differences in recirculation times between normal and nude or irradiated rats, and also the time‐scales seen in long‐term thoracic duct cannulations.