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Priming of T‐Cell Responses in Mice by Porins of Salmonella typhimurium
Author(s) -
Sudhir Gupta
Publication year - 1998
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1046/j.1365-3083.1998.00326.x
Subject(s) - priming (agriculture) , biology , apoptosis , population , immunology , t cell , cytokine , secretion , microbiology and biotechnology , programmed cell death , immune system , medicine , biochemistry , botany , germination , environmental health
An imbalance in signals delivered to T cells via T‐cell receptor and accessory molecules can lead to anergy, apoptosis, or both. In the present study we have demonstrated that Salmonella typhimurium infection in mice leads to a progressive loss of CD4 + T helper (Th) cell population, abnormal T‐cell death by apoptosis and loss of accessory molecules (B7 and intracellular adhesion molecule‐1) on macrophages. Quantification of interleukin‐2 (IL‐2), interleukin‐4 (IL‐4) and interferon‐γ (IFN‐γ) secretion revealed a Th2‐type of response in lymphocytes isolated from spleen. However, preimmunization of mice with porins resulted in an increased CD4 + Th cell population and accessory molecules on the surface of macrophages. Quantification of cytokines revealed a Th1‐type of response. We conclude that preimmunization of mice with porins provides a microenvironment in which a well‐balanced accessory molecule and cytokine network is established, which results in the prevention of cell death by apoptosis.