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Allotype‐Associated Differences in Concentrations of Human IgA 2
Author(s) -
Petri S. Mattila,
Ilkka Seppälä,
Heikki Sarvas,
O. Mãkelä
Publication year - 1998
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1046/j.1365-3083.1998.00277.x
Subject(s) - allotype , immunoglobulin e , allele , antibody , immunoglobulin a , significant difference , immunology , biology , chemistry , immunoglobulin g , medicine , genetics , gene
Concentrations of immunoglobulin (Ig)A 2 were determined in 176 Finnish blood donor sera. Their IgA, IgM, IgE, IgG 1 , IgG 2 , IgG 3 and IgG 4 concentrations and Gm allotypes had been determined earlier. The mean concentration of IgA 2 was higher in individuals carrying the Gm(ax) allele (0.15 g/l) than in those negative for Gm(x) (0.103 g/l). The difference was statistically significant ( P = 0.006). As ≥ 70% of IgA was usually IgA 1 , its concentration could be calculated fairly reliably by subtracting the IgA 2 value from the IgA value. The mean IgA 1 concentration (2.03 g/l) seemed to be independent of the Gm allotypes.