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Lack of Polarized Type 1 or Type 2 Cytokine Profile in Asymptomatic HIV‐1‐Infected Patients During a Two‐Year Bimonthly Follow‐Up
Author(s) -
Canaris,
Arnaldo Caruso,
Licenziati,
Cantalamessa,
Maria Antonia De Francesco,
Fallacara,
Simona Fiorentini,
Dima,
Martinelli,
Jean Manca,
Andrea Balsari,
Turano
Publication year - 1998
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1046/j.1365-3083.1998.00270.x
Subject(s) - asymptomatic , cytokine , peripheral blood mononuclear cell , medicine , immunology , interferon gamma , interferon , biology , in vitro , biochemistry
The production of type 1 (interferon or IFN‐γ) and type 2 (interleukin or IL‐4 and IL‐10) cytokines by mitogen‐stimulated peripheral blood mononuclear cells (PBMCs) obtained from asymptomatic human immunodeficiency virus‐seropositive (HIV + ) patients untreated with any antiviral, antibacterial or antimycotic drugs, and from healthy individuals, was evaluated by quantitative ELISA. Patients who were HIV + were characterized by the absence of abnormal cytokine production. The level of each cytokine differed among individuals in the same group with intersubject variations greater for HIV + patients than for healthy individuals. The longitudinal evaluation of IFN‐γ, IL‐4 and IL‐10 production showed intrasubject variations which were particularly marked in HIV + patients. Accordingly, HIV + patients and, to a lesser extent, healthy individuals were characterized by a wide spectrum of possible profiles, which were confined to type 0 phenotype. In HIV + patients no correlation was found between each cytokine level and the number of CD4 + T cells, not even in those with a falling CD4 + T‐cell count and clinical symptoms.