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Immunological Induction of Flavour Aversion in Mice. II. Passive/Adoptive Transfer and Pharmacological Inhibition
Author(s) -
CARA D. C.,
CONDE A. A.,
VAZ N. M.
Publication year - 1997
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1046/j.1365-3083.1997.d01-363.x
Subject(s) - ovalbumin , taste aversion , histamine , spleen , immune system , adjuvant , adoptive cell transfer , immunology , chemistry , biology , endocrinology , medicine , biochemistry , t cell , taste
Mice immunized with ovalbumin develop a strong aversion to ingesting sweetened egg white dilutions or ovalbumin solutions. In immunized animals, gavage or voluntary ingestion of ovalbumin triggers an increase of vascular permeability in the intestine; pretreatment with a mixture of histamine and serotonin antagonists blocked this reaction, but not the aversion; dexamethasone inhibited both the aversion and the increase in permeability. The aversion was transferred to normal recipient mice with high‐titre anti‐Ova sera obtained with complete Freund’s adjuvant, but not with lower‐titre serum pools of mice immunized with the help of Al(OH) 3 adjuvant. However, the aversion was also (adoptively) transferred with whole spleen cells from immune donors. This later condition is inefficient to transfer the formation of high titres of specific antibodies.