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Difference in Binding of Killed and Live Streptococcus pneumoniae Serotypes by C‐Reactive Protein
Author(s) -
DE BEAUFORT A. J.,
LANGERMANS J. A. M.,
MATZEVAN DER LANS A. M.,
HIEMSTRA P. S.,
VOSSEN J. M.,
VAN FURTH R.
Publication year - 1997
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1046/j.1365-3083.1997.d01-171.x
Subject(s) - streptococcus pneumoniae , opsonin , microbiology and biotechnology , phagocytosis , serotype , bacteria , staphylococcus aureus , biology , streptococcaceae , streptococcus , antibody opsonization , antibiotics , genetics
The binding and opsonic properties of C‐reactive protein (CRP) for various species of bacteria were investigated. CRP bound more avidly to killed than to live Streptococcus pneumoniae , the binding varying among various serotypes; CRP hardly bound to a number of other bacterial species studied. CRP enhanced complement‐dependent phagocytosis of live S. pneumoniae by granulocytes but did not enhance the phagocytosis of live Staphylococcus aureus or group B streptococci. We suppose that CRP may serve as an opsonin for killed bacteria and bacterial debris but is probably not an important opsonin for live bacteria other than S. pneumoniae .