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Induction of HIV‐1 Specific Mucosal Immune Responses by DNA Vaccination
Author(s) -
ASAKURA Y.,
HINKULA J.,
LEANDERSSON A.C.,
FUKUSHIMA J.,
OKUDA K.,
WAHREN B.
Publication year - 1997
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1046/j.1365-3083.1997.d01-146.x
Subject(s) - immune system , dna vaccination , vaccination , immunology , human immunodeficiency virus (hiv) , dna , virology , biology , medicine , genetics , immunization
DNA vaccination has been shown to induce immunity against several different pathogens including HIV‐1. The authors demonstrate here that administration of DNA vaccines via the intranasal route is sufficient to induce immune responses both at distal mucosal sites and systemically. Since transmission of HIV‐1 occurs largely across mucosal surfaces, the intranasal route provides a further means of application for DNA immunization.