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High Levels of Neutralizing Autoantibodies Against IL‐1α are Associated with a Better Prognosis in Chronic Polyarthritis: a Follow‐Up Study
Author(s) -
JOUVENNE P.,
FOSSIEZ F.,
BANCHEREAU J.,
MIOSSEC P.
Publication year - 1997
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1046/j.1365-3083.1997.d01-139.x
Subject(s) - polyarthritis , medicine , autoantibody , incidence (geometry) , rheumatoid arthritis , antibody , immunology , rheumatoid factor , arthritis , disease , interleukin 6 , gastroenterology , cytokine , physics , optics
Neutralizing autoantibodies to interleukin (IL)‐1α were detected in a subset of chronic polyarthritis patients characterized by an increased proportion of patients with primary Sjögren's syndrome or self‐limiting inflammatory arthritis, diseases with a much better prognosis than rheumatoid arthritis (RA). The evolution of anti‐IL‐1α antibody levels was followed over 3 years. Incidence and levels were higher in patients with a benign form of polyarthritis. In these patients levels remained stable or increased over the follow‐up period. In contrast, incidence and levels were lower and some RA patients became negative. Negative correlations were observed between the levels of anti‐IL‐1α antibodies and the clinical and biological indices of disease activity. The relative risk factor of developing RA was 12 in the absence of high anti‐IL‐1α antibody levels and 18.2 when associated with the presence of HLA‐DR4. In conclusion, the presence of anti‐IL‐1α autoantibodies appears to be protective and their detection could represent a marker of good prognosis for destruction.