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Decreases in CD5 + B Lymphocytes in Children with the DiGeorge Anomaly
Author(s) -
KOURTIS A. P.,
IBEGBU C. C.,
LEE F. K.,
VOGLER L.,
PHILIPS K.,
NAHMIAS A. J.
Publication year - 1997
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1046/j.1365-3083.1997.d01-127.x
Subject(s) - digeorge syndrome , anomaly (physics) , function (biology) , cd5 , immunology , lymphocyte , medicine , biology , genetics , antibody , physics , condensed matter physics
The authors evaluated the lymphocyte subsets in eight children with the DiGeorge anomaly, compared with 48 age‐matched control infants. Of particular interest was the finding that the percentage and number of CD5 + B lymphocytes were decreased in seven of the eight cases. This observation may provide insight into thymic function and the interaction of the B and T cell systems in some forms of congenital and acquired immunodeficiencies.