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Induction of Human Cytotoxic T Lymphocytes by Oxidized Low Density Lipoproteins
Author(s) -
WU R.,
GISCOMBE R.,
HOLM G.,
LEFVERT A. K.
Publication year - 1996
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1046/j.1365-3083.1996.d01-51.x
Subject(s) - cytotoxic t cell , chemistry , immunology , biology , microbiology and biotechnology , biochemistry , in vitro
Oxidized low density lipoproteins (oxLDL) stimulated human blood T cells to a specific cytotoxic response which autologous PHA activated blood mononuclear cells which had been pre‐incubated with oxLDL. The cytotoxic reaction was exerted by CD8 + enriched cells but not by CD4 + enriched cells. Allogeneic target cells from HLA mismatched donors were not damaged and the reaction was consistently inhibited by monoclonal antibody against HLA class I. Antigen‐specific cytotoxic T cells might contribute to lysis of cells in the atherosclerotic plaque that have taken up oxLDL and thus participate in the inflammatory process associated with atherosclerosis.