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Cytokine Production in Hearts of Trypanosoma cruzi ‐Infected CBA Mice: Do Cytokine Patterns in Chronic Stage Reflect the Establishment of Myocardial Pathology?
Author(s) -
SUNNEMARK D.,
ULFGREN A.K.,
ÖRN A.,
HARRIS R. A.
Publication year - 1996
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1046/j.1365-3083.1996.d01-328.x
Subject(s) - cytokine , trypanosoma cruzi , chagas disease , immunology , pathology , cd8 , biology , fibrosis , myocarditis , tumor necrosis factor alpha , medicine , immune system , parasite hosting , world wide web , computer science
The authors analysed cytokine production in hearts of Trypanosoma cruzi ‐infected CBA‐J mice by in situ immunocytochemical staining. Cellular infiltrates were recorded in hearts from both acute and chronic stages, but were not apparent in control hearts. In the acute heart, CD8 cells predominated, with associated production of IL‐4, IL‐6 and TNF‐α. Cytokine production was characterized by IL‐4, IL‐5, IL‐6 and TNF‐α in the chronic heart, and numbers of CD4 and CD8 cells were more equal. At this stage, calcified infarctions and associated fibrosis were apparent, mimicking chronic human Chagas' heart pathology. The authors consider the CBA mouse an appropriate model of chronic T. cruzi infection, and suggest that local cytokine production reflects establishment of heart pathology.