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Primitive Cytokines and Cytokine Receptors in Invertebrates: the Sea Star Asterias rubens as a Model of Study
Author(s) -
LEGAC E.,
VAUGIER G.L.,
BOUSQUET F.,
BAJELAN M.,
LECLERC M.
Publication year - 1996
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1046/j.1365-3083.1996.d01-322.x
Subject(s) - asterias , receptor , immune system , cytokine , biology , star (game theory) , invertebrate , immunology , microbiology and biotechnology , starfish , ecology , physics , genetics , astrophysics
It has been previously demonstrated that the sea star axial organ is a primitive immune organ. Phagocytic, lymphoid‐like cells have been characterized with properties similar to those of vertebrates. There is also evidence for an invertebrate cytokine network because IL‐1 and TNF‐like activities are clearly demonstrable. In addition, the authors have previously described preliminary evidence for IL‐2‐like activity in the sea star. In the present report, the authors obtained evidence for the presence of IL‐1‐ and IL‐2‐like molecules on axial organ cells. More interestingly, the results suggested that sea star cells express structures similar to human receptors for IL‐1, IL‐2, IL‐6 and IFN‐γ.