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Long‐Lasting Immune Response Induced by Recombinant Bacillus Calmette–Guérin (BCG) Secretion System
Author(s) -
WADA N.,
OHARA N.,
KAMEOKA M.,
NISHINO Y.,
MATSUMOTO S.,
NISHIYAMA T.,
NAITO M.,
YUKITAKE H.,
OKADA Y.,
IKUTA K.,
YAMADA T.
Publication year - 1996
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1046/j.1365-3083.1996.d01-28.x
Subject(s) - epitope , secretion , recombinant dna , immune system , virology , biology , antigen , antibody , microbiology and biotechnology , extracellular , bacillus (shape) , mycobacterium kansasii , immunology , mycobacterium , bacteria , biochemistry , genetics , gene
The recombinant bacillus Calmette–Guérin (rBCG) secretion system utilizing an extracellular α antigen of Mycobacterium kansasii (α‐K) was characterized biochemically and immunologically. The human immunodeficiency virus type1 (HIV‐1) p17 gag B cell epitope fused to α‐K was secreted in extremely large amounts. At least three mice out of seven inoculated with rBCG generated high titres of antibody to the epitope. The long‐lasting antibody production persisted more than 14 months.