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Interleukin 10 Release During Endotoxaemia in Chimpanzees: Role of Platelet‐Activating Factor and Interleukin 6
Author(s) -
VAN DER POLL T.,
JANSEN J.,
LEVI M.,
TEN CATE H.,
HACK C. E.,
AARDEN L. A.,
TEN CATE J. W.,
VAN DEVENTER S. J. H.
Publication year - 1996
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1046/j.1365-3083.1996.d01-12.x
Subject(s) - platelet activating factor , interleukin , platelet , chemistry , immunology , endocrinology , antagonist , pharmacology , medicine , cytokine , receptor
Interleukin (IL‐)10 has been demonstrated to inhibit endotoxin‐induced production of a number of pro‐inflammatory cytokines. The present study sought to compare the appearances in the circulation of IL‐10, IL‐6 and IL‐8, and to assess the roles ofendogenously produced platelet‐activating factor (PAF) and IL‐6 in IL‐10 release during endotoxaemia in chimpanzees. Intravenous injection of endotoxin (lot EC‐5, 4 ng/kg, n = 8) induced a transient rise in serum IL‐10concentrations, peaking after 2 h (213 ± 70 pg/ml; P < 0.05). No correlations existed between peak IL‐10 levels, and peak IL‐6 and IL‐8 levels. Neither infusion of the specific PAF antagonist TCV‐309( n = 4), nor infusion of a neutralizing anti‐IL‐6 monoclonal antibody ( n = 4) influenced endotoxin‐induced IL‐10 release. IL‐10 release elicited by injection of endotoxin is not mediated by PAF or IL6. Tom van der Poll MD, Academic Medical Center, Department of Internal Medicine, F4222, Meibergdreef 9, 1105 AZ Amsterdam, the Netherlands