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Increased immunoglobulin secretion by B lymphocytes from Trypanosoma cruzi infected mice after B lymphocytes–natural killer cell interaction
Author(s) -
De Arruda Hinds Luciana B.,
AlexandreMoreira Magna Suzana,
DecotéRicardo Débora,
Nunes Marize P.,
Peçanha Ligia M.T.
Publication year - 2001
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1046/j.1365-3024.2001.00418.x
Subject(s) - biology , secretion , antibody , immunology , b cell , trypanosoma cruzi , natural killer cell , stimulation , lymphokine activated killer cell , immune system , interleukin 21 , t cell , cytotoxic t cell , in vitro , endocrinology , parasite hosting , biochemistry , world wide web , computer science
In the present study, we investigated whether natural killer (NK) cells modulate immunoglobulin (Ig) secretion by B cells from Trypanosoma cruzi ‐infected mice. B cells from infected mice increased IgM and IgG2a secretion in the presence of a NK cell line, and this response was cell contact‐dependent. Stimulation of splenic B cells with polyinosinic‐polycytidylic acid, a NK cell activator, also increased Ig secretion by B cells from infected mice. B cells from infected mice expressed higher levels of the B7·2 molecule. Our results suggest that NK cells may be involved in the control of the abnormal B cell activation observed during T. cruzi infection.